Analysis of group randomized trials with multiple binary endpoints and small number of groups.

Analysis of group randomized trials with multiple binary endpoints and small number of groups.

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The group randomized trial (GRT) is a common study design to assess the effect of an intervention program aimed at health promotion or disease prevention.In GRTs, groups rather than individuals are randomized into intervention or control arms.Then, responses are measured on individuals within those groups.A number of analytical problems On-board Multi-User Detection Algorithm Based on Conditional Neural Process beset GRT designs.

The major problem emerges from the likely positive intraclass correlation among observations of individuals within a group.This paper provides an overview of the analytical method for GRT data and applies this method to a randomized cancer prevention trial, where multiple binary primary endpoints were obtained.We develop an index of extra variability to investigate group-specific effects on response.The purpose of the index is to understand the influence of individual groups on evaluating the intervention effect, especially, when a GRT study involves a small number of groups.

The multiple Enhancing reproductive health among adolescent girls in India: results of an individualized RCT to study the efficacy of the go Nisha go mobile game endpoints from the GRT design are analyzed using a generalized linear mixed model and the stepdown Bonferroni method of Holm.